(Mono-)ethyleenglycol kan ook omgezet worden tot di-ethyleenglycol door het te laten reageren met etheenoxide. [60] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. VII. [6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. Soon thereafter, patients died after receiving the medication. Under normal conditions, diethylene glycol has no detectable odor; however, under high vapor concentrations, a slightly sweet odor may be detected. Laboratory findings in clinical assessment of diethylene glycol can include an elevated osmolar gap, elevated anion gap, elevated creatinine, and acidosis [8,11,12]. Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH 2 OH) 2. Structure, properties, spectra, suppliers and links for: Diethylene glycol n-butyl ether, 112-34-5. They also arrested 12 people in connection with the incident. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. They have closely related structures; a diethylene glycol is a combination of to ethylene glycol molecules. Food Chem., 34(1), 1986, 140-144. O’Neil M. The Merck Index. Investigations revealed that all had taken a medicine called “My Pikin Baby”, a teething mixture tainted with diethylene glycol. Chemsrc provides Diethylene glycol(CAS#:111-46-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. This value indicates that diethylene glycol dibenzoate will be essentially nonvolatile from water surfaces (2,SRC). Diethylene glycol. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Video shows what diethylene glycol means. For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. 86-13. Jump to navigation Jump to search. Linear Formula C 2 H 5 OCH 2 CH 2 OCH 2 CH 2 OH . skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. Laboratory testing at CDC of samples taken from parents revealed significant contamination with DEG. DEG is a widely used solvent. [3] Food Chem., 50, 2002, 7616-7621. ass: Standard polar; Column diameter: 0.32 mm; Column length: 50 m; Column type: Capillary; Heat rate: 2 K/min; Start T: 50 C; End T: 200 C; End time: 40 min; Start time: 5 min; CAS no: 111466; Active phase: Carbowax 20M; Carrier gas: He; Data type: Linear RI; Authors: Chen, C.-C.; Kuo, M.-C.; Liu, S.-E.; Wu, C.-M., Volatile components of salted and pickled prunes (Prunus mume Sieb. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. Synonym: 2-(2-Ethoxyethoxy)ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Ethyldiglycol Linear Formula: C 2 H 5 OCH 2 CH 2 OCH 2 CH 2 OH Molecular Weight: 134.17 Daarbij wordt mono-, di- en tri-ethyleenoxide gevormd, die door destillatie gescheiden worden. Diethylene Glycol is a colorless, low-volatility, low viscosity, hygroscopic liquid. It can react with sulfuric acid and other dehydrating agents, nitric acid, oxygen, hydrogen peroxide, perchloric acid and strong acids. 120-55-8 - NXQMCAOPTPLPRL-UHFFFAOYSA-N - Diethylene glycol dibenzoate - Similar structures search, synonyms, formulas, resource links, and other chemical information. ; Pietroluongo, M.; de Maria, C.A.B., Flavor composition of cashew (Anacardium occidentale) and marmeleiro (Croton species) honeys, J. Agric. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. 106.120. Name of substance DIETHYLENE GLYCOL Identifiers CAS No 111-46-6 Molecular formula C4H10O3 Molar mass 106.1 g/mol SECTION 4: First-aid measures 4.1 Description of first- aid measures General notes Safety Data Sheet acc. [2] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. [39], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. Name of substance DIETHYLENE GLYCOL Identifiers CAS No 111-46-6 Molecular formula C4H10O3 Molar mass 106.1 g/mol SECTION 4: First-aid measures 4.1 Description of first- aid measures General notes Safety Data Sheet acc. Diethylene glycol butyl ether is a high boiling solvent, which can be used in coating industry. Suspecting something wrong with Lisinopril, the medicine was removed from the pharmacies[39] while the U.S. Food and Drug Administration conducted lab analyses, revealing the blood pressure drug was safe; CDC epidemiologists were then invited to participate. Diethylene glycol structure. Laboratory findings in clinical assessment of diethylene glycol can include an elevated osmolar gap, elevated anion gap, elevated creatinine, and acidosis [8,11,12]. CAS Number. Beilstein/REAXYS Number 1736441 . Diethylene glycol (DEG) is employed as a comonomer during the synthesis of poly (ethylene terephthalate) (PET). [23][24][25], After recalling millions of wine bottles, the Austrian Government had no idea how to destroy the product. Once verifying that he was fine, he shipped it to Qiquihar No. The Himachal Pradesh government is filing a criminal case against the company and its executives. % in diethylene glycol monobutyl ether/ethylene glycol, 99.9% trace metals basis Sigma-Aldrich pricing Global Diethylene Glycol Methyl Ethyl Ethe Market Report to cover Industrial Chain Analysis, Manufacturing Cost Structure, Process Analysis December 17, 2020 6 Min Read Panamanian officials traced the toothpaste to a local company in the Colón Free Trade Zone. 2005-03-26. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. a clear, hygroscopic, odorless liquid, which is described by chemical structure formula HO-CH2-CH2-O-CH2-CH2-OH. [70], In the first week of 2020, around 17 children from Ramnagar, in the union territory of Jammu and Kashmir, were hospitalised, more than half of whom died of kidney failure. Not to be confused with dimethoxymethane or dimethyl ether. The death rate of this mysterious illness was nearly 50%, when hospital management decided to isolate all the patients with the illness in a large room and doctors could compare notes and theories. [14][15], In 1937, S.E. [1][7], At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. In July 1996, the American Embassy in China contacted Sinochem and requested a list of Chinese glycerin makers, but the company refused to reveal the names. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. It undergoes oxidation on treatment with nitric acid. [45] Spanish authorities are prosecuting Asunción Criado, general manager of Rasfer Internacional, S.A., and await Panamanian citizens, René Luciani (former Social Security Director) and Jéssica Rodríguez (former Purchase National Director) for their hearings. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: Diethylene glycol has been detected in drinking water, ground water, surface water, and indoor air resulting from its release to the environment from its production and use. U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration ethanol, 2- (2-ethoxyethoxy)-, ethanol, 2- (2-ethoxyethoxy)-, ethanol, 2- (2-ethoxyethoxy)-, c0py00051e, b818488g. It has a molecular weight of around 30 000 and its polyethylene oxide segments have an average molecular weight of about 1000. 111-46-6. Retention indices of amines in some polar and unpolar stationary phases, Latv. III. It is a humectant for tobacco, cork, printing ink, and glue. Once DEG reaches the liver, it is metabolized by enzymes. Diethylene glycol is one of several glycols derived from ethylene oxide. diethylene synonyms, diethylene pronunciation, diethylene translation, English dictionary definition of diethylene. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. [70] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. MDL number MFCD00002881. Sigma-Aldrich offers a number of Diethylene glycol products. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. They identified Tianhong Fine Chemicals Factory as the manufacturer. File:Diethylene glycol structure.svg. The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. Diethylene glycol. Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH 2 OH) 2. [29], When a patient admitted for a heart attack developed the mysterious illness at the hospital, Dr. Nestor Sosa, an infectious disease specialist, analyzed the medical record. Commun., 34, 1969, 767-775. umn class: Standard polar; Column length: 3 m; Column type: Packed; Start T: 200 C; CAS no: 111466; Active phase: PEG-2000; Carrier gas: He; Substrate: Celite 545 (44-60 mesh); Data type: Kovats RI; Authors: Anderson, A.; Jurel, S.; Shymanska, M.; Golender, L., Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. DEG is a widely used solvent. Mass Spectral Interpretation A. Glycols and Glycol Ethers (Underivatized) In the mass spectra of di- and tri-ethylene glycol, the largest peak observed is at m/z 45. Diethylene glycol is one of several glycols derived from ethylene oxide. In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. Under normal conditions, diethylene glycol has no detectable odor; however, under high vapor concentrations, a slightly sweet odor may be detected. It is a colorless, practically odorless, poisonous, hygroscopic liquid with a sweetish taste. [1][7], Based on available literature, scientists suggest unmetabolized DEG and HEAA are partially reabsorbed through glomerular filtration. When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. Despite the discovery of DEG’s toxicity in 1937 and its involvement in mass poisonings around the world, the information available regarding human toxicity is limited. [61], Ending November 2008, infants started to die after developing unexplained fevers and vomiting. Mr. Wang was caught and Qiquihar was shut down by the authorities. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. [39] Immediately, biological samples and the syrup were sent by jet to CDC for analysis. [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. , CDC scientists recalled the Nigeria and Haiti incidents Ministry of Public Works started testing a diethylene glycol structure of wine salt. Two months and seven years care products ( Afebril and Valodon ) and illness la... Odorless, colorless, low-volatility, low-viscosity, hygroscopic liquid with a sweetish taste contradictory symptoms records revealed the had... Cream and lotions, deodorants ), manufactured sulfanilamide dissolved with diethylene glycol a... 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